The effect of erythropoietin on ovarian epithelium edema during ischemia reperfusion injury in rats

  • Constantinos Tsompos
  • C. Panoulis Assistant Professor, Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki
  • K Τοutouzas Assistant Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Athena, Attiki
  • A. Triantafyllou Associate Professor, Department of Biologic Chemistry, Athens University, Athens, Attiki
  • G. Ζografos Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki
  • A. Papalois Director, Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki
Keywords: Ovarian epithelium edema, Reperfusion, Erythropoietin


Object: This experiment investigated a probable recessing effect of erythropoietin (Epo) in a rat model of ovarian ischemia-reperfusion (IR) injury concerning the mean ovarian epithelium edema (OE) lesions.

Methods: 40 rats of mean weight 247.7 g were used totally. The OE lesions scores were evaluated at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion; after Epo administration in groups C and D.

Results: Epo administration non-significantly decreased the OE scores by 0.3 without lesions [-0.8356043 - 0.2356043] (p= 0.2803). Reperfusion time kept non-significantly increased the OE by 0.35 without lesions [-0.2356043 - 0.8356043] (p=0.2557). However, erythropoietin administration and reperfusion time together non-significantly decreased the OE scores by 0.1272727 without lesions [-0.4530022 - 0.1984567] (p=0.4339).

Conclusion: Epo administration showed a non-significant short-term recessing trend for OE scores without lesions alteration. Perhaps, a longer study time than 2 hours or a higher Epo dosage may reveal clearer and significant effects.  


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