Research Journal of Pharmacology and Toxicology 2017-05-21T05:18:43+00:00 Editor in Chief Open Journal Systems <p>Research Journal of Pharmacology and Toxicology (RJPT) in&nbsp;monthly&nbsp;online peer reviewed &nbsp;journal of Pharmacology and toxicology.</p> The effect of erythropoietin on ovarian epithelium edema during ischemia reperfusion injury in rats 2017-05-21T05:18:43+00:00 Constantinos Tsompos C. Panoulis K Τοutouzas A. Triantafyllou G. Ζografos A. Papalois <p><strong>Object:</strong> This experiment investigated a probable recessing effect of erythropoietin (Epo) in a rat model of ovarian ischemia-reperfusion (IR) injury concerning the mean ovarian epithelium edema (OE) lesions.</p> <p><strong>Methods:</strong> 40 rats of mean weight 247.7 g were used totally. The OE lesions scores were evaluated at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion; after Epo administration in groups C and D.</p> <p><strong>Results:</strong> Epo administration non-significantly decreased the OE scores by 0.3 without lesions [-0.8356043 - 0.2356043] (p= 0.2803). Reperfusion time kept non-significantly increased the OE by 0.35 without lesions [-0.2356043 - 0.8356043] (p=0.2557). However, erythropoietin administration and reperfusion time together non-significantly decreased the OE scores by 0.1272727 without lesions [-0.4530022 - 0.1984567] (p=0.4339).</p> <p><strong>Conclusion:</strong> Epo administration showed a non-significant short-term recessing trend for OE scores without lesions alteration. Perhaps, a longer study time than 2 hours or a higher Epo dosage may reveal clearer and significant effects.&nbsp;&nbsp;</p> 2017-05-11T02:28:07+00:00 ##submission.copyrightStatement##