The effect of the antioxidant drug “U-74389G” on creatine kinase - MB levels during ischemia reperfusion injury in rats

  • Constantinos Tsompos
  • Constantinos Panoulis Assistant Professor, Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki
  • Konstantinos Toutouzas Assistant Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki,
  • Aggeliki Triantafyllou Associate Professor, Department of Biologic Chemistry, Athens University, Athens, Attiki,
  • George Zografos Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki
Keywords: ischemia, U-74389G, creatine kinase - MB, reperfusion

Abstract

Background: This experimental study examined the effect of the antioxidant drug “U-74389Gâ€, on a rat model and particularly in a liver ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean creatine kinase - MB (CK-MB) levels.

Methods: 40 rats of mean weight 231.875 g were used in the study. CK-MB levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D.

Results: U-74389G administration kept significantly increased the CK-MB levels by 31.60% + 13.10% (p = 0.0148). Reperfusion time kept non-significantly increased the CK-MB levels by 5.40% + 14.09% (p= 0.6358). However, U-74389G administration and reperfusion time together kept non-significantly increased the CK-MB levels by 14.50% + 8.16% (p=0.0745).

Conclusions: U-74389G administration reduced at non-significantly increased the CK-MB levels, getting on decline them from significant to non-significant level.

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Published
2017-04-11
Issue
Vol 2 No 2 (2016): RJPT
Section
Original Articles

Copyright (c) 2016 Research Journal of Pharmacology and Toxicology

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