The effect of the antioxidant drug “U-74389G” on testosterone levels during ischemia reperfusion injury in rats

  • C. Tsompos Consultant A, Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania,
  • C. Panoulis Assistant Professor, Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki
  • K Τοutouzas Assistant Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki
  • A. Triantafyllou Associate Professor, Department of Biologic Chemistry, Athens University, Attiki
  • G. Ζografos Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki
  • A. Papalois Director, Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, attiki
Keywords: ischemia, U-74389G, testosterone levels, reperfusion

Abstract

Background: This experimental study examined the effect of the antioxidant drug “U-74389Gâ€, on a rat model and particularly in an adrenal ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean testosterone (T) levels.

Materials and methods: 40 rats of mean weight 231.875 g were used in the study. Testosterone levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D), A and B without but C and D with U-74389G administration.

Results: U-74389G administration significantly increased the T levels by 52.17%+28.69% (p=0.0451). Reperfusion time significantly decreased the T levels by 85.62%+26.33% (P= 0.0019). However, U-74389G administration and reperfusion time together produced a non-significant combined effect in increasing the T levels by 11.18%+17.97% (p= 0.5245).

Conclusions: U-74389G administration interacted or not with reperfusion time increased short – term the testosterone levels.         

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Published
2015-12-30
Issue
Vol 2 No 1 (2016): RJPT
Section
Original Articles

Copyright (c) 2016 Research Journal of Pharmacology and Toxicology

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