The acute effect of the antioxidant drug “U-74389G” on mean corpuscular volume levels during hypoxia reoxygenation injury in rats

  • Constantinos Tsompos Department of Obstetrics & Gynecology Mesologi County Hospital Nafpaktou street Mesologi 30200, Etoloakarnania
  • Constantinos Panoulis Assistant Professor, Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki
  • Konstantinos Toutouzas Assistant Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki
  • Aggeliki Triantafyllou Associate Professor, Department of Biologic Chemistry, Athens University, Attiki
  • George Zografos Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki
  • Apostolos Papalois Director, Experimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki
Keywords: hypoxia, mean corpuscular volume, U-74389G, reoxygenation

Abstract

Background: This experimental study examined the effect of the antioxidant drug “U-74389Gâ€, on a rat model and particularly in a hypoxia – reoxygenation (HR) protocol. The effects of that molecule were studied hematologically using mean blood corpuscular volume (MCV) levels.

Methods: 40 rats of mean weight 231.875 g were used in the study. MCV levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D) with administration of the drug U-74389G in groups C and D.

Results: U-74389G administration significantly increased the predicted MCV levels by 2.88%+0.69 (p= 0.0002). Reoxygenation time non-significantly increased the MCV levels by 0.57%+0.83% (p=0.4103). However, U-74389G administration and reoxygenation time together significantly increased the MCV levels by 1.60%+0.43% (p= 0.0005).

Conclusions: U-74389G administration whether it interacted or not with reoxygenation time has significant increasing short – term effect on recovery pathophysiology of MCV values.

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Published
2016-08-16
Issue
Vol 1 No 5 (2015): RJPT
Section
Original Articles

Copyright (c) 2016 Research Journal of Pharmacology and Toxicology

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