Effect of Sodium Lauryl Sulfate (SLS) on the External Adnexia of the Rabbit Eye
Abstract
SLS is an anionic surfactant used in the production of personal hygiene products such as tooth pastes, soaps, shampoos, shaving foam and other consumable related products. This study evaluated the effect of SLS on the tissues of the external adnexia of rabbit eye Varying doses of SLS (5mg/ml and 10mg/ml) was instilled on the eyes of New Zealand rabbits and the ocular status was observed for five days using a 20X magnification lens. It was observed that SLS was toxic to the external adnexia of the eye and caused some morphological changes. There was swelling of the eyelid, hyperemia in conjunctiva, tearing, discharge, photophobia and edema which were visible from up to day five with optimal changes on day three. The effect was dose dependent and more significant in animals instilled with 10mg/ml of SLS solution. The results suggest that SLS was toxic to the rabbit eye and increased dose could increase toxic effect on the eye. This study has exposed the effect of SLS to the eye and recommends minimal concentration in cosmetics and household hygienic detergents that can get direct contact with the eye.
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