Comparative in vitro anti-oxidative properties of statins

  • Gerard Q. De Guzman College of Pharmacy, Virgen Milagrosa University Foundation, Martin P. Posadas Ave., San Carlos City, Pangasinan, Philippines 2420
  • Mafel C. Ysrael Research Center for the Natural and Applied Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
  • Aleth Therese L. Dacanay Faculty of Pharmacy, Main Bldg., University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
  • Shiela DV Miranda The Graduate School, Thomas Aquinas Research Complex, University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
  • Grecebio Jonathan D. Alejandro Office for Graduate Research, The Graduate School, Thomas Aquinas Research Complex, University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
Keywords: statin, anti-oxidants

Abstract

Introduction:  This study seeks to determine and compare the in vitro anti-oxidative properties of 5 statins which aare available in the market for the treatment of dyslipidemia. 

Methods:  The ability of the statins to inhibit free radical formation by 2,2-Diphyenyl-1-Picrylhydrazyl (DPPH) and thiobarbituric aci d (TBA) in liver homogenates was determined. 

Results:  Out of the 5 statins tested, atorvastatin, simvastatin and rosuvastatin gave the highest inhibibition and lowest median effective concentration (IC50).  Pravastatin and fluvastatin were weak inhibitors of free radical formations. 

Conclusion:  This study shows that there is evidence on the anti-oxidative properties of statins in addition to their hypolipidemic properties.

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Author Biographies

Gerard Q. De Guzman, College of Pharmacy, Virgen Milagrosa University Foundation, Martin P. Posadas Ave., San Carlos City, Pangasinan, Philippines 2420
Professor 1
Mafel C. Ysrael, Research Center for the Natural and Applied Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
Director
Aleth Therese L. Dacanay, Faculty of Pharmacy, Main Bldg., University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
Faculty Secretary
Shiela DV Miranda, The Graduate School, Thomas Aquinas Research Complex, University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
Ph.D. in Pharmacy Student
Grecebio Jonathan D. Alejandro, Office for Graduate Research, The Graduate School, Thomas Aquinas Research Complex, University of Santo Tomas, Espana Blvd., Sampaloc, Manila, Philippines 1015
Director

References

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Shishehbor, M.H., Brennan, M., Aviles, R.J., Fu, X., Penn, M.S., Sprecher, D.L. and Hazen, S.L. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation 2003; 108: 426-431.

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Gupta, R.C., Sharma, V., Sharma, N. Kumar, N. and Singh, B. In vitro antioxidant activity from leaves of Oroxylum indicum (L.) Vent. - A north Indian highly threatened and vulnerable medicinal plant. J. Phar. Res. 2008; 1 (1): 65-72.

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Published
2015-06-12
Issue
Vol 1 No 1 (2015): RJPT
Section
Original Articles

Copyright (c) 2015 Research Journal of Pharmacology and Toxicology

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