Design and Development of Fast Disintegrating Tablet to form Sustained Release Suspension of Cefixime by Extrusion and Spheronization Technique
Abstract
The aim of present research work was undertaken with the objective of design and development of Fast disintegrating tablet to form sustained release suspension of Cefixime by Extrusion and Spheronization technique using sodium alginate, Eudragit RS100 and Eudragit RL100 as a release retardant polymer for geriatric and pediatric patients. Pellets were prepared by Extrusion and Spheronization technique using various concentration of polymer (sodium alginate, Eudragit RS100 and RL100). Pellets were evaluated for % drug loading, % friability, flow property, particle size, CPR and statistical data was evaluated. Optimize batch of pellets was used in formulation of Fast Disintegrating Tablets by using 32 factorial design.Â
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