Potential role of organic sulfur compounds from Allium in cancer prevention and therapy
AbstractThe anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and their specific organo-sulfur compounds of garlic. The anticarcinogenic and antitumorigenic characteristics appear through both dose and sequentially related changes in cellular events involved with the cancer process, including those involving drug metabolism, immune-competence, cell cycle regulation, apoptosis, and angiogenesis. The ability of garlic and related allyl sulfur compounds to block tumors in the colon, lung, breast, and liver. Few studies have compared the relative efficacy of water and lipid soluble allyl sulfur compounds, when using chemically induced carcinogen models and suggested little difference in responses, whereas tumor proliferation/apoptosis is highly dependent on the species provided. A shift in sulfhydryl groups, alterations in glutathione: oxidized glutathione ratios, and resultant changes in cellular redox status may be involved in some of the phenotypic changes caused by allyl sulfur compounds. Such changes in thiols by allyl sulfurs may also account for the observed hyperphosphorylation of specific cell cycle proteins and the histone hyper acetylation that has correlated with suppressed tumor cell proliferation. Whereas the anticarcinogenic and antitumorigenic data are impressive and more studies are needed to exposures the allyl sulfur compounds anticancer activities.
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