Evaluation of apo-lipoproteins and troponin levels in post-menopausal women in Nnewi Metropolis, Anambra state, Nigeria
Introduction: The global burden of cardiovascular diseases (CVD) is rapidly increasing. It is the leading cause of death in women around the world. This study investigated the Apo-Lipoproteins and Troponin Levels in Post-Menopausal Women in Nnewi Metropolis, Anambra State, Nigeria.
Methods: A total of 120 subjects comprising of 60 apparently healthy post-menopausal and premenopausal women (control) aged between 50 to 70 years and 20 to 30 years respectively were recruited for the study. Their demographic data, blood pressure readings, andbody mass index (BMI) were obtained using a well-structured questionnaire. Thereafter, 5mls of blood sample was collected from the subjects into plain container and used for the estimation of biochemical parameters (Apo A-I, Apo B, Apo C-II, and Troponin I levels) respectively using standard laboratory methods. Data obtained were subjected to statistical analysis using student t-test and Pearson r correlation.
Observations and results: The results showed that the mean serum concentrations of Apo B (0.68±0.38 Vs 0.43±0.18g/L); Apo C-II(0.06±0.01 Vs 0.05±0.01g/L) and Troponin I (0.23±0.07 Vs 0.10±0.08ng/ml) were significantly increased in postmenopausal women than in the control subjects (P=0.000), whereas the mean serum Apo A-I concentration (0.20±0.07 Vs 0.48±0.18g/L) was significantly decreased in postmenopausal women than in the control subjects (P=0.000). Interestingly, the mean BMI did not differ significantly in both subjects (P=0.540). More so, there were significant increase in the SBP (136.95±10.55 Vs 108.67±10.88) and DBP (93. 58±8.49 Vs 80. 33±7.21) in the postmenopausal women than in the control subjects (P=0.000). Again, there were no significant correlation observed in parameters studied in both subjects (p>0.05).
Conclusion: These findings revealed that the incidence of coronary heart disease may be associated with menopause. Therefore, lifestyle modifications should be incorporated into the daily lives of menopausal women.
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