Tissue Engineering in Periodontics – A Review

  • C. D. Dhalkari Associate Professor, Department of Periodontology, GDC, Aurangabad, Maharashtra
  • Pallav Ganatra Post-graduate Student, Department of Periodontology, GDC, Aurangabad, Maharashtra
  • Pawan Sawalakhe Post-graduate Student, Department of Periodontology, GDC, Aurangabad, Maharashtra
  • Abhishek Singh Nayyar Associate Professor, Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra,
Keywords: periodontal regeneration, recombinant therapeutics

Abstract

Tissue engineering is a highly promising field of reconstructive biology that draws on recent advances in medicine, surgery, molecular and cellular biology, polymer chemistry, and physiology. The objective of using tissue engineering as therapeutic application has been to harness its ability to exploit selected and primed cells together with an appropriate mix of regulatory factors to allow growth and specialization of cells and matrix. The authors reviewed controlled clinical trials which also included histological studies that evaluated the potential of tissue engineering as a clinical tool in regeneration. PubMed/MEDLINE databases were searched for studies up to and including June 2010 to identify appropriate articles. A comprehensive search was designed, and the articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal regeneration were included. Studies demonstrated that periodontal regeneration with the use of combination of tissue engineered products with an osteoconductive matrix improve the beneficial effect of these materials by accelerating cellular in-growth and revascularization of the wound site. Studies have suggested the use of Platelet-derived growth factor alongwith beta tricalcium phosphate for regeneration of the periodontal attachment apparatus in combination with collagen membranes as an acceptable alternative to connective tissue graft for covering gingival recession defects. These studies concluded that growth factors promote true regeneration of the periodontal attachment apparatus and the use of combination protein therapeutics could provide more predictable, faster, and less invasive, less traumatic and efficient outcome for the patients.

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References

Taba M Jr, Jin Q, Sugai JV, Giannobile WV. Current concepts in periodontal bioengineering. Orthod Craniofac Res 2005;8:292-302.

Kao RT, Conte G, Nishimine D, Dault S. Tissue engineering for periodontal regeneration. J Calif Dent Assoc 2005;33:205-15.

Risbud MV, Shapiro IM. Stem cells in craniofacial and dental tissue engineering. Orthod Craniofac Res 2005;8:54-9.

Pradeep AR, Karthikeyan BV. Tissue engineering: Prospect for regenerating periodontal tissues. Indian J Dent Res 2003;14:224-9.

Zhao M, Jin Q, Berry JE, Nociti FH Jr, Giannobile WV, Somerman MJ. Cementoblast delivery for periodontal tissue engineering. J Periodontol 2004;75:154-61.

Nakashima M, Reddi AH. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol 2003;21:1025-32.

Jin QM, Anusaksathien O, Webb SA, Rutherford RB, Giannobile WV. Gene therapy of bone morphogenetic protein for periodontal tissue engineering. J Periodontol 2003;74:202-13.

Giannobile WV. What does the future hold for periodontal tissue engineering? Int J Periodontics Restorative Dent 2002;22:6-7.

Ripamonti U, Tasker JR. Advances in biotechnology for tissue engineering of bone. Curr Pharm Biotechnol 2000;1:47-55.

Bartold PM, McCulloch CA, Narayanan AS, Pitaru S. Tissue engineering: A new paradigm for periodontal regeneration based on molecular and cell biology. Periodontol 2000 2000;24:253-69.

Kuboki Y, Sasaki M, Saito A, Takita H, Kato H. Regeneration of periodontal ligament and cementum by BMP-applied tissue engineering. Eur J Oral Sci 1998;106:197-203.

Ripamonti U, Reddi AH. Tissue engineering, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins. Crit Rev Oral Biol Med 1997;8:154-63.

Giannobile WV. Periodontal tissue engineering by growth factors. Bone 1996;19:23S-37S. Review.

Published
2015-10-11
How to Cite
1.
Dhalkari C, Ganatra P, Sawalakhe P, Nayyar A. Tissue Engineering in Periodontics – A Review. AMS [Internet]. 11Oct.2015 [cited 21Feb.2020];2(7):102-4. Available from: http://asdpub.com/index.php/ams/article/view/254
Section
Review Articles

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