Quantitative Estimation of Biochemical and Inorganic Constituents Present in the GallStones
Carcinoma of gallbladder has an unusual geographic distribution. Gallbladder cancer is the most common type of biliary tract cancer which is the fifth most common gastrointestinal tract cancer and sixth most common digestive tract malignancy. Thus, the study was carried out based on quantitative analysis of biochemical constituents (cholesterol, bilirubin, bile acids, fatty acids, phospholipids and soluble protein) and inorganic constituents (sodium, potassium, calcium, magnesium, inorganic phosphate, oxalate and chloride) in all the three types of gallstones and also compare the present findings with other researchers findings. The results indicated that out of 179 gallstones, 41 were of cholesterol type, 77 mixed and 61 of pigment type. Cholesterol content was found to be the major component in all the three types of stones. Also, cholesterol stones had higher content of total cholesterol, fatty acids, phospholipids and inorganic phosphates as compared to mixed stones and pigment stones. While in case of pigment stones bilirubin, bile acids, soluble protein, sodium, potassium, calcium were found to be higher as compared to cholesterol and mixed stones. The overall findings with respect to biochemical constituents resulted that the cholesterol saturation is mostly responsible for crystallization sequences in human gallbladder.
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