Study of Chemotherapy Induced Nausea and Vomiting In Children With Malignancy

  • Saumya Das Department of Pharmaceutical Technology, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh
  • Rani Rahat Department of Pharmaceutical Technology, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh
  • Gauri Kapoor Rajiv Gandhi Cancer Hospital and Research Centre, Delhi
Keywords: Anti-emetics, chemotherapy-induced nausea and vomiting, NCCN standard guidelines, malignancy

Abstract

OBJECTIVE: To study chemotherapy induced nausea and vomiting (CINV) and efficacy of antiemetics in children (<18 years of age) treated for pediatric cancers with cancers chemotherapy regimens having moderate or high emetogenic potential.

METHOD: This was a prospective observational study, which assessed the current usage, Chemotherapy cycles in subjects, which met the eligibility criteria were studied for chemotherapy induced nausea and vomiting (CINV), using National Cancer Institute (NCI) Common Toxicity Criteria. A total of 50 patients who met the study criteria were enrolled in to the study. All the data pertaining to reason for the antiemetic agents used were based on the emetogenic potential of the chemotherapy protocols. The main objective was to document the prescribing and administration of antiemetic and collect data on the incidence of CINV with the purpose of studying the effectiveness of antiemetic medication used.

RESULT AND DISCUSSION: It was observed in our study that use of ondansetrone was according to standard guidelines. Hence although fairly good control of emesis was recorded for moderate emetogenic regimens, strategies for further improvement in antiemetic schedule for high emetogenic schedules should be considered. vincristine-actinomycin-cyclophosphamide had the highest rate of emesis while high dose methotrexate had the best control.

CONCLUSION: Hence although fairly good control of emesis was recorded for moderate emetogenic regimens, strategies for further improvement in antiemetic schedule for high emetogenic schedules should be considered. Among the various chemotherapy schedules used, it was observed that rate of acute emesis control was poorest with vincristine-actinomycin-cyclophosphamide and best control was observed with high dose methotrexate. This observation may be kept in mind when planning the anti-emetic protocol for these regimes.

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References

Coates A (1983) on the receiving and patients perception of the side effects of cancer chemotherapy. European journal of cancer and Clinical Oncology. 19, 2, 203-208.

Ronald, Fischer (2005) Delayed vomiting in children with cancer after receiving moderately high and highly emetogenic chemotherapy. Journal of Pediatric Oncology Nursing. 24, 2, 70-80.

Anti-emetic Subcommittee of the Multinational Association of Supportive Care in Cancer (2006) Prevention of chemotherapy and radiotherapy-induced emesis: results of the 2004 perugia International Anti-emetic Consensus Conference. Annals of Oncology. 17, 1, 20-28.

Bloechl-Daum (2006) Delayed nausea and vomiting continue to reduced patient’s quality of life after highly and moderately emetogenic chemotherapy despite anti-emetic treatment. Journal of Clinical Oncology. 24, 27, 4472-4478.

Molassiotis A (2006) A Nausea and vomiting. In Kearney N (Eds) Nursing Patients with Cancer Principles and Practice. Churchill Livingstone, London.22-25.

Robinson DL, Carr BA (2007) Delayed vomiting in children with cancer after receiving moderately high and highly emetogenic chemotherapy. Journal of Pediatric Oncology Nursing. 24, 2, 70-80.

Published
2015-05-21
How to Cite
1.
Das S, Rahat R, Kapoor G. Study of Chemotherapy Induced Nausea and Vomiting In Children With Malignancy. AMS [Internet]. 21May2015 [cited 22Feb.2020];2(1):33-6. Available from: http://asdpub.com/index.php/ams/article/view/122
Section
Original Articles

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