Study of Chemotherapy Induced Nausea and Vomiting In Children With Malignancy
Abstract
OBJECTIVE: To study chemotherapy induced nausea and vomiting (CINV) and efficacy of antiemetics in children (<18 years of age) treated for pediatric cancers with cancers chemotherapy regimens having moderate or high emetogenic potential.
METHOD: This was a prospective observational study, which assessed the current usage, Chemotherapy cycles in subjects, which met the eligibility criteria were studied for chemotherapy induced nausea and vomiting (CINV), using National Cancer Institute (NCI) Common Toxicity Criteria. A total of 50 patients who met the study criteria were enrolled in to the study. All the data pertaining to reason for the antiemetic agents used were based on the emetogenic potential of the chemotherapy protocols. The main objective was to document the prescribing and administration of antiemetic and collect data on the incidence of CINV with the purpose of studying the effectiveness of antiemetic medication used.
RESULT AND DISCUSSION: It was observed in our study that use of ondansetrone was according to standard guidelines. Hence although fairly good control of emesis was recorded for moderate emetogenic regimens, strategies for further improvement in antiemetic schedule for high emetogenic schedules should be considered. vincristine-actinomycin-cyclophosphamide had the highest rate of emesis while high dose methotrexate had the best control.
CONCLUSION: Hence although fairly good control of emesis was recorded for moderate emetogenic regimens, strategies for further improvement in antiemetic schedule for high emetogenic schedules should be considered. Among the various chemotherapy schedules used, it was observed that rate of acute emesis control was poorest with vincristine-actinomycin-cyclophosphamide and best control was observed with high dose methotrexate. This observation may be kept in mind when planning the anti-emetic protocol for these regimes.
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References
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