Neurodevelopment Hypothesis of Schizophrenia and the Structural Neuroimaging as a Tool to Prove it

  • Andriana Kakanakova Department of Psychiatry and Psychology, Medical University, Plovdiv,15 A ,V.Aprilov.Blvd, Plovdiv
Keywords: Computer Tomography findings, Schizophrenia, Neurodevelopment hypothesis

Abstract

Abstract: According to the neurodevelopment hypothesis of schizophrenia it is a disorder due to brain damaging during the intrauterine or early childhood years, manifesting decades later symptomatically.

In a metaanalysis in 2001, 193 magnetic resonance imaging (MRI) structural studies have been reviewed.

The data confirmed earlier findings by computer tomography (CT) studies – consistent enlargement of the lateral and third ventricles and decreased volume of the temporal lobe.

Decreased volume of the whole brain, ventricular dilatation, widening of the brain sulci are features defining brain atrophy.

The most common CT markers of defining the brain atrophy are:

1.Internal cerebrospinal fluid amplitudes:

Frontal horns index (FHI); Huckmann’s number (HZ); Cella media index (CMI); III and IV ventricle amplitudes.

2.External cerebrospinal fluid amplitudes:

Cizternae insulares, Frontal interhaemispheric sulcus, Number of the sulci, Sulci width

3.Temporal lobe amplitude

The new directions of studying the structural anomalies of the schizophrenic brain lean towards studying more homogenic groups of patients, linking the changes to actual stages of the disorder, comparing structural with functional changes.

Downloads

Download data is not yet available.

References

Murray RM, Bramon E In: BJ Sadock, VA Sadock, eds., 12.5 Developmental Model of Schizophrenia Part of "12 - Schizophrenia and Other Psychotic Disorders" Kaplan and Sadock's Comprehensive Textbook of Psychiatry, 8th ed. Philadelphia: Lippincott Williams and Wilkins, 2005

Clementz BA, Iacono WG, Ficken J, Beiser M. A family study of nailfold plexus visibility in psychotic disorders. Biol Psychiatry. 1992;31:378-390.

Waddington JL, Weller MPI. Schizophrenia, genetic retrenchment and epidemilogical renaissance. Arch Gen Psychiatry 1992; 49: 990-994.

Cannon, M., Jones, P. B., Murray, R. M. [2002] Obstetric complications and schizophrenia: Historical and meta-analytic review. Am J Psychiat, 159:1080-1092.

Cantor-Graae E, McNeil T, Sjostrom K, Nordstrom L, Rosenlund T. Obstetric complications and their relationship to other etiological risk factors in schizophrenia. J Nerv Ment Dis 1994; 182 (11): 645-650.

Feinberg I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res 1982/1983; 17:319-334.

Buka SL, Tsuang MT, Lipsitt LP. Pregnancy/delivery complications and psychiatric diagnosis. A prospective study. Arch Gen Psychiatry 1993; 50: 151-156.

O'Callaghan E, Cotter D, Colgan C, Larkin C, Walsh D, Waddington JL. Confinement of winter birth excess in schizophrenia to those born in cities and its gender specificity. Br J Psychiatry 1995; 166 (1): 51-54.

Daniel DG, Goldberg TE, Gibbons RD, Weinberger DR: Lack of a bimodal distribution of ventricular size in schizophrenia: A Gaussian mixture analysis of 1056 cases and controls. Biol Psychiatry. 1991;30:887.

Walker, E., Lewine, R. J. [1990] Prediction of adult-onset schizophrenia from childhood home movies of the patients. Am J Psychiatry, 147:1052-6.

Wright P, Gill M, Murray RM. Schizophrenia: genetics and the maternal immune response to viral infection. Am J Med Genet (Neuropsych Genet) 1993; 48: 40-46.

Warner R, De Girolamo G. Schizophrenia. VOZ, Geneva, 1996

Bradbury TN, Miller GA. Season of birth in schizophrenia: a review of evidence, methodology, and etiology. Psychol Bull 1985;98:569-594,

Buchsbaum MS, and Haier RJ, Psychopathology: Biological approaches. Annual Review of Phys¬iology 34:401-430, 1.983.

O'Callaghan E, Gibson T, Colohan HA, et al. Season of birth in schizophrenia: evidence for confinement of an excess of winter births to patients without a family history of mental disorder. Br J Psychiat 1991; 158: 764-769.

El-Khodor BF, Boksa P. Transient birth hypoxia increases behavioral responses to repeated stress in the adult rat. Behav Brain Res. 2000;107:171–175.

Martha E. Shenton Ph.D.,Marek Kubicki M.D., Ph.D., Editors:Sadock, Benjamin J.; Sadock, Virginia A.; Ruiz, Pedro,Title: Kaplan & Sadock's Comprehensive Textbook of Psychiatry, 9th Edition Copyright ©2009 Lippincott Williams & Wilkins.

Hulka BS. Wilcosky TC. Griffith JS. Biological Markers in Epidemiology. New York, Oxford University Press, 1990.

Buckley PF, Dean D, Bookstein FL, et al. A three-dimensional morphometric study of craniofacial shape in schizophrenia. Am J Psychiatry. 2005;162:606-608

Keshavan MS, Anderson S, Pettegrew JW. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex—the Feinberg hypothesis revisited. J Psychiatr Res. 1994:28(3):239–265. Library Holdings.

Vesela Georgieva, Stefan Sivkov, Valentin Akabaliev, Yvetta Koeva, Roumiana Angelova, Tania Deneva [2007] CT Findings of Structural Brain Abnormalities in Schizophrenic Patients in Support of the Neurodevelopmental Hypotesis of the Disorder, Folia Medica XLIX11-15.

Gur RE. Temporolimbic volume reductions in schizophrenia. Arch Gen Psychiatry. 2000; 57:769

Weinberger OR. Computed tomography (CT) findings in schizophrenia: speculation on the meaning of it all. J Psychiatr Res 1984; 1 8:477-490.

Olabi, B., Ellison-Wright, I., McIntosh, A. M., Wood, S. J., Bullmore, E., Lawrie, S. M. [2011] Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies. Biol Psychiat, 70:88-96.

Weinberg, S. M., Jenkins, E. A., Marazita, M. L., Maher, B. S. [2007] Minor physical anomalies in schizophrenia: a metaanalysis. Schizophr Res, 89:72-85.

Ðœ.ЛеÑев, Ð.Танева, КомпютъртомографÑка диагноÑтика на мозъчната атрофиÑ, Ð¡Ð¾Ñ„Ð¸Ñ 1999г.

Published
2015-05-21
How to Cite
1.
Kakanakova A. Neurodevelopment Hypothesis of Schizophrenia and the Structural Neuroimaging as a Tool to Prove it. AMS [Internet]. 21May2015 [cited 21Nov.2024];2(1):01-3. Available from: https://asdpub.com/index.php/ams/article/view/62
Section
Review Articles

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.