Membrane depolarization in stroke patients

  • Nnodim Johnkennedy Department of Medical Laboratory Sciences, Faculty of Health Sciences, Imo State University Owerri
  • Nwobodo Emmanuel Department of Biochemistry, ChukwuemekaOdumegwuOjukwu University Uli Anambra State
  • Nwadike Constance 1Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri, Imo State
  • Edward Ukamaka Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri, Imo State
  • Okorie Hope 1Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri, Imo State
  • Obi Patrick Federal Medical CentreOwerri Imo State
Keywords: Membrane depolarization, stroke, membrane potential

Abstract

Aim: This study was investigated to evaluate the level of membrane potential in stroke patients in Owerri.

Material and method:   60 stroke patients and 60 apparently healthy subjects between the ages of 60 to 80years admitted to General Hospital Owerri were selected in this study. Fasting veinous blood was collected and was used for the determination of membrane potential .

Results: The results obtained revealed that the level of membrane potential was significantly decreased in stroke patients when compared with the control at P<0.05.

Conclusion: This could probably imply depolarization of cell membrane potential leading to              reduced cell activity.

Downloads

Download data is not yet available.

References

1.Ziganshina, LE; Abakumova, T; Vernay, L (2016). Cerebrolysin for acute ischaemic stroke.The Cochrane database of systematic reviews. 12: 7026-7030
2.Sardar, P; Chatterjee, S; Giri, J; Kundu, A; Tandar, A; Sen, P; Nairooz, R; Huston, J; Ryan, JJ; Bashir, R; Parikh, SA; White, CJ; Meyers, PM; Mukherjee, D; Majersik, JJ; Gray, WA (2015). Endovascular therapy for acute ischaemic stroke: a systematic review and meta-analysis of randomized trials. European Heart Journal. 36: 2373–2380.
3.Saver, Jeffrey L.; Goyal, Mayank; van der Lugt, Aad; Menon, Bijoy K.; Majoie, Charles B. L. M (2016). "Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis". JAMA. 316 (12): 1279–1288.
4.Badhiwala, JH; Nassiri, F; Alhazzani, W; Selim, MH; Farrokhyar, F; Spears, J; Kulkarni, AV; Singh, S; Alqahtani, A; Rochwerg, B; Alshahrani, M; Murty, NK; Alhazzani, A; Yarascavitch, B; Reddy, K; Zaidat, OO; Almenawer, SA (2015). Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis. JAMA. 314 (17): 1832-1843
5.Brady, Marian C.; Kelly, Helen; Godwin, Jon; Enderby, Pam; Campbell, Pauline (2016). Speech and language therapy for aphasia following stroke. The Cochrane Database of Systematic Reviews (6): 425-427.
6.Saunders, DH; Sanderson, M; Brazzelli, M; Greig, CA; Mead, GE (2013). Physical fitness training for stroke patients.The Cochrane database of systematic reviews. 10: 3316-3318.
7.Barclay RE, Stevenson TJ, Poluha W, Ripat J,Nett C, Srikesavan CS (2015). Interventions for improving community ambulation in individuals with stroke.Cochrane Database of Systematic Reviews. (3): 10200-10205.
8.Fryer CE, Luker JA, McDonnell MN, Hillier SL (2016). Self management programmes for quality of life in people with stroke.Cochrane Database of Systematic Reviews. (8):10442 -10444
9.Mackenzie, C (2011). Dysarthria in stroke: A narrative review of its description and the outcome of intervention. International Journal of Speech-Language Pathology: 125–136.
10.Hamilton RH, Chrysikou EG, Coslett B (2011). Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain Lang. 118 (1–2): 40–50
11. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O'Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C (2014). Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 383 (9913): 245–54.
12.Nnodim JK., Nsonwu M., Obioma-Elemba JE., Nwadike C., Edward U., Njokuobi T., and Jimoh RF (2016) Decreased Magnesium level and membrane potential of glaucoma patients. UniversaMedicina 35(2):111-115
13. NnodimJk, Meludu SC, CE Dioka CE, Onah C, ChilakaUJ , Obi PC (2014). Altered Membrane Potential and Electrolyte in Sickle Cell Anemia Journal of Krishna Institute of Medical Sciences University.3(1):70. -73

14.De Lima, LG; Saconato, H; Atallah, AN; da Silva, EM (2014). Beta-blockers for preventing stroke recurrence. The Cochrane database of systematic reviews. 10: 7890-7891
15. Callies, C; Fels, J; Liashkovich, I; Kliche, K; Jeggle, P; Kusche-Vihrog, K; Oberleithner, H (2011). Membrane potential depolarization decreases the stiffness of vascular endothelial cells. Journal of Cell Science. 124: 1936–1942.
16.Larsson SC, Virtamo J, Wolk A (2011). Red meat consumption and risk of stroke in Swedish men.American Journal of Clinical Nutrition. 94 (2): 417–421.
17.Wilson, D.; Adams, M. E.; Robertson, F.; Murphy, M.; Werring, D. J. (2015). Investigating intracerebral haemorrhage.BMJ. 350 (10): h2484–h2484
18.Hackam, DG ( 2016). Prognosis of Asymptomatic Carotid Artery Occlusion: Systematic Review and Meta-Analysis..Stroke; a Journal of cerebral circulation. 47 (5): 1253–7
19.Shah, A. S. V.; Lee, K. K.; McAllister, D. A.; Hunter, A.; Nair, H.; Whiteley, W.; Langrish, J. P.; Newby, D. E.; Mills, N. L. (2015). Short term exposure to air pollution and stroke: systematic review and meta-analysis. BMJ. 350 (11): h1295–h1295
20.Bennett, MH; Weibel, S; Wasiak, J; Schnabel, A; French, C; Kranke, P (2014). Hyperbaric oxygen therapy for acute ischaemic stroke.The Cochrane database of systematic reviews. 11: 4954-4957.
Published
2017-05-10
How to Cite
1.
Johnkennedy N, Emmanuel N, Constance N, Ukamaka E, Hope O, Patrick O. Membrane depolarization in stroke patients. AMS [Internet]. 10May2017 [cited 14Nov.2024];3(4):09-1. Available from: https://asdpub.com/index.php/ams/article/view/352
Issue
Vol 3 No 4 (2016): AMS
Section
Original Articles

Copyright (c) 2016 Acta Medica Scientia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

A) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

B) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

C) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.