Role of Peritoneal Fluid Cytology in Gynaecological Cancers

  • Tanushri Mukherjee Department of Oncopathology, Command Hospital Kolkata,

Abstract

Intraperitoneal dissemination of disease is an important cause of morbidity and mortality among women with genital tract cancers.Peritoneal Fluid cytology is indispensable for diagnosis, prognosis,staging and ancillary studies in gynaecological Cancers.  Peritoneal fluid was examined for the presence of tumor cells in 94 patients with ovarian and  endometrial cancer. The findings were correlated with the type, grade, and stage of the tumor. Fluids that were positive for malignant cells were associated with serous and endometrioidcarcinomas  of ovary more often than with carcinomas of other types. Patients with high-stage tumors of all types had positive fluids more often than those with low-stage tumors. The presence of tumor cells in the fluid indicated a worse prognosis at 2 years. Analysis of other factors that influence prognosis, however, revealed that this difference was related more specifically to the stage of the disease. Since the presence of tumor cells in abdominal fluid is a factor in the subclassification of Stage I and Stage II ovarian cancer, analysis of a larger group of patients with tumors in these stages is needed to establish the prognostic significance of positive cytological findings independent of other prognostic factors.

Downloads

Download data is not yet available.

References

Creasman WT, Rutledge F. The prognostic value of peritoneal cytology in gynecologic malignant disease.Am J Obstet Gynecol. 1971 Jul 15;110(6):773–781.

Keettel WC, Pixley EE, Buchsbaum HJ. Experience with peritoneal cytology in the management of gynecologic malignancies. Am J Obstet Gynecol. 1974 Sep 15;120(2):174–182.

Creasman WT, Disaia PJ, Blessing J, Wilkinson RH, Jr, Johnston W, Weed JC.,Jr Prognostic significance of peritoneal cytology in patients with endometrial cancer and preliminary data concerning therapy with intraperitoneal radiopharmaceuticals. Am J Obstet Gynecol. 1981 Dec 15;141(8):921–929

Yazigi R, Piver MS, Blumenson L. Malignant peritoneal cytology as prognostic indicator in stage I endometrial cancer. Obstet Gynecol. 1983 Sep;62(3):359–362

DAHLE T. Transtubal spread of tumor cells in carcinoma of the body of the uterus. SurgGynecol Obstet. 1956 Sep;103(3):332–336.

HOEG K. Superficial dissemination of cancer of the uterine body; cytological examination of smears from the tubes and the pouch of Douglas. J ObstetGynaecol Br Emp. 1956 Dec;63(6):899–902.

Szpak CA, Creasman WT, Vollmer RT, Johnston WW. Prognostic value of cytologic examination of peritoneal washings in patients with endometrial carcinoma.ActaCytol. 1981 Nov-Dec;25(6):640–646.

Published
2015-03-30
How to Cite
1.
Mukherjee T. Role of Peritoneal Fluid Cytology in Gynaecological Cancers. AMS [Internet]. 30Mar.2015 [cited 21Nov.2024];2(3):63-4. Available from: https://asdpub.com/index.php/ams/article/view/161
Section
Review Articles

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.