Effect of high intake of heavy metals from environmental air and in food in diabetic patients

Abstract

Diabetes mellitus is an endocrine disorder and affecting millions of people. It remains latent and its secondary obstacles leads to the mortality and morbidity. Various metal such as arsenic, beryllium, cadmium and nickel have been linked with the occurrence of diabetes mellitus in peoples exposed to these elements. Some elements like iron and copper are crucial minerals that are necessary for a variety of molecules to maintain their normal structures, functions of cells to existence, grow, and multiply. The homeostasis of iron and copper is coordinated regulation by different proteins concerned in uptake, excretion and intracellular storage or transferring. This study connected airborne levels of these metals with diabetes mortality. The lowest air levels detected were beryllium and cadmium, with nickel showing the highest levels. This supported diabetes mortality effects of air pollution and correlating arsenic, beryllium, cadmium and nickel with diabetes incidence. Although iron is essential but it can be toxic in high amounts. Iron is a transit mineral can generate various reactive oxygen or nitrogen species so abnormal metabolism of iron can lead to numerous chronic pathogenesis. Oxidative stress is one of the main contributing factors for diabetes and diabetic problems. Iron overload may increases risks of insulin resistance and diabetes.