Malaria and treatment: Herbal antimalarials as alternative to conventional medicine

  • Engwa Azeh Godwill Biochemistry, Chemical Sciences Department, Godfrey Okoye University, P.M.B 01014, Thinkers Corner, Enugu
Keywords: malaria, conventional medicine, resistance, treatment, safety, herbal medicine, efficacy

Abstract

For decades, malaria treatment has been championed by conventional medicine through chemotherapy. This was evident until the late 20th century when problems of treatment failure were observed as a result of the emergence of plasmodium parasite resistance.  In addition, the safety of some of these drugs could not be guaranteed as were found to be toxic and produce adverse effect. In search for solutions to the challenges of chemotherapy enveloped the emergence of herbal medicine as possible alternatives. Today herbal medicine is appreciated worldwide for the treatment of so many diseases and malaria. This paper reviews the current status of malaria and its management with references to treatment by chemotherapy. It also enumerates the pitfalls of conventional medicine which laid the foundation of herbal medicine on malaria treatment. Key herbal antimalarial plants and studies of their efficacy and safety are cited. In addition to their safety, some herbals plants were shown in some studies to be effective against resistant parasite strains. In conclusion, emphases on the contributions of herbal treatments in the management of malaria are outlined with possible suggestion to ensure quality using good manufacturing practices for a better management of malaria in the future.

Downloads

Download data is not yet available.

References

Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI, 2005. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature, 434:214-217.

John Luke Gallup and Jeffrey D. Sachs, 2001. The Economic Burden of Malaria. Am. J. Trop. Med. Hyg., 64(1, 2) S: 85–96

World Malaria Report, 2012. Fact Sheet. www.who.int/malaria, December 2012.

World Health Organisation, 2010. Guidelines for the treatment of malaria, 2nd edition. WHO Library Cataloguing-in-Publication Data.

David Bell and Peter Winstanley, 2004. Current issues in the treatment of uncomplicated malaria in Africa. British Medical Bulletin 71: 29–43

Harald Noedl, Youry Se, Sabaithip Sriwichai, Kurt Schaecher, Paktiya Teja-Isavadharm, Bryan Smith, Wiriya Rutvisuttinunt, Delia Bethell, Sittidech Surasri, Mark M. Fukuda, Duong Socheat, and Lon Chan Thap, 2010. Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia. Clinical Infectious Diseases, 51(11):e82–e89

Taylor WR and White NJ, 2004. Antimalarial drug toxicity: a review. Drug Saf. 27(1):25-61.

Gyasi RM, Mensah CM, Adjei PO & Agyemang S, 2011. Public Perceptions of the Role of Traditional Medicine in the Health Care Delivery System in Ghana. Global Journal of Health Science, 3 (2) 40-49: doi:10.5539/gjhs.v3n2p40.

Dana G. Dalrymple, 2012. Artemisia annua, Artemisinin, ACTs & Malaria Control in Africa. Tradition, Science and Public Policy. Politics & Prose Bookstore, 5015 connecticut ave, N.W. Washington D.C.

World Health Organization, 1999. Malaria, 1982–1997. Wkly Epidemiol Rec 74: 265–270.

World Health Organization, 1997. World malaria situation in 1994, part I. Wkly Epidemiol Rec 72: 269–274.

The Prescriber, 2000. Promoting Rational Use of Drugs and Correct Case Management in Basic Health Services. UNICEF Programme Division, 3 UN Plaza, New York 10017

Tobler W, Deichmann U, Gottsegen J, Maloy K, 1995. The Global Demography Project. National Center for Geographic Information and Analysis. Technical Report TR-95-6.

World Bank, 1998. World Development Indicators 1998 CDROM. Washington, DC: International Bank for Reconstruction and Development.

World Health Organization, 1992. World malaria situation in 1990, part II. Wkly Epidemiol Rec 67: 169–174.

Pampana EJ, Russell PF, 1955. Malaria: A World Problem. Geneva: World Health Organization.

Ascenzi A,1999. Malaria diseases and parasites. Parassitologia, 41:33-38.

Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B, 2002. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419:489-511.

Shortt HE, Garnham PCC, Covell G, Shute PG, 1948. The pre-erythrocytic stage of human malaria Plasmodiun vivax. Brit Med J, 1:547.

Bray RS, 1960. Studies on malaria in chimpanzees. VIII. The experimental transmission and pre-erythrocytic phase of Plasmodium malariae with a note on the host range of the parasite. Amer J Trop Med Hyg, 9:455-65.

Garnham PCC, Bray RS, Cooper W, Lainson R, Awad FI, Williamson J, 1954. Preerythrocytic stages of human malaria: Plasmodium ovale. A preliminary note. Brit Med J, 1:257.

Singh B, Lee KS, Matusop A, Radhakrishnan A, Shamsul SSG, Cox-Singh J, Thomas A, Conway DJ, 2004. A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet, 363:1017-24.

Francis EG Cox, 2010. History of the discovery of the malaria parasites and their vectors. Cox Parasites & Vectors, 3:5. http://www.parasitesandvectors.com/content/3/1/5

CDC treatment guidelines, 2013 Treatment of Malaria (Guidelines For Clinicians). http://www.cdc.gov/malaria/resources/pdf/treatmenttable.pdf

World Health Organization, 1966. Malaria eradication in 1965.WHO Chron 20: 286–300.

Sanjeev Krishnaa, Anne-Catrin Uhlemanna, Richard K. Haynesb, 2004. Artemisinins: mechanisms of action and potential for resistance. Drug Resistance Updates 7: 233–244.

Talisuna AO, Langi P, Bakyaita N, Egwang T, Mutabingwa TK, Watkins W, Van ME, and D’Alessandro U, 2002. Intensity of malaria transmission, antimalarial-drug use and resistance in Uganda: what is the relationship between these three factors? Transaction of the Royal Society of Tropical Medicine and Hygiene, 96:310–7.

Wernsdorfer H. N, and Walther H, 2003. Molecular markers for drug resistance in malaria: use in treatment, diagnosis and epidemiology. Current Opinion in Infectious Diseases, 16:553–558.

Rogers W, Sem R, Tero T, et al. 2009. Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malaria J 8(1):1-9.

Taylor WR, White NJ, 2004. Antimalarial drug toxicity: a review. Drug Safety , 27:25–61.

Surgeon General of the United States, 1943. In: The drug treatment of malaria, suppressive and clinical. Circular letter no. 153. J. Am. Med. Assoc. 123, 205–208.

Baird, J.K., 2011. Resistance to chloroquine unhinges vivax malaria therapeutics. Antimicrob. Agents Chemother. 55, 1827–1830.

Sanjoy Kumar Pal, Yogeshwer Shukla, 2003. Herbal Medicine: Current Status and the Future. Asian Pacific J Cancer Prev, 4, 281-288

Vickers A and Zollman C, 1999. ABC of complementary medicine: herbal medicine. BMJ, 319, 1050 -3.

World Health Organization, 1998. Quality control methods for medicinal plants materials. Geneva.

Evans M, 1994. A guide to herbal remedies. Orient Paperbacks.

Dobson MJ, 1998. Bitter–sweet solutions for malaria: exploring natural remedies from the past. Parassitologia 40, 69–81.

Greenwood D, 1992. The quinine connection. J. Antimicrob. Chemother. 30, 417–427.

Klayman DL, 1985. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049–1055.

Qinghaosu C-ORGo, 1977. Kuo Xue Tung Bao 22, 142.

Qinghaosu C-ORGo, 1979. Antimalaria studies on Qinghaosu. Chin. Med. J. (Engl.) 92, 811–816.

Satish Bahekar1, Ranjana Kale, 2013. Herbal Plants Used For the Treatment of Malaria- A Literature Review. Journal of Pharmacognosy and Phytochemistry. 1 (6): 141-146

Willcox ML, Bodeker G, 2004. Traditional herbal medicines for malaria. BMJ. Nov 13329(7475):1156-1159.

Bora U, Sahu A, Saikia AP, Ryakala VK, Goswami P, 2007. Medicinal plants used by the people of Northeast India for curing malaria. Phytother Res. 21(8):800-804.

Nguyen-Pouplin J, Tran H, Tran H, et al. 2007. Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam. J Ethnopharmacol. 109(3):417-427.

Muregi FW, Chhabra SC, Njagi EN, et al. 2004. Anti-plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine. Phytother Res. 18(5):379-384.

Willcox ML, 1999. A clinical trial of 'AM', a Ugandan herbal remedy for malaria. J Public Health Med. 21(3):318-324.

Muregi FW, Chhabra SC, Njagi EN, et al. 2004. Anti-plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine. Phytother Res. 18(5):379-384

Bletter N, 2007. A quantitative synthesis of the medicinal ethnobotany of the Malinke of Mali and the Ashaninka of Peru, with a new theoretical framework. J Ethnobiol Ethnomed. 5;3(1):36.

Carraz M, Jossang A, Franetich J-F, et al. 2006. A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages. PLoS Med. 2006; 3(12):e513.

Tran QL, Tezuka Y, Ueda JY, et al. 2003. In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. J Ethnopharmacol. 86(2-3):249-252.

Published
2015-07-07
How to Cite
Godwill, E. (2015). Malaria and treatment: Herbal antimalarials as alternative to conventional medicine. Research Journal of Phytomedicine, 1(1), 04-07. Retrieved from http://asdpub.com/index.php/rjp/article/view/162
Section
Review Articles