Carbohydrate-lipid interactions in obesity and diabetes
The current worldwide epidemic of obesity and type 2 diabetes has increased simultaneously with adverse metabolic events. There is expansive evidence that the type of carbohydrate consumed is important in the development or prevention of insulin resistance, obesity, and the metabolic syndrome. There is scarcity of published data on the combined effects of interactions between micronutrients, carbohydrates and lipids. However, there are extensive data supporting the benefits of the effects of both carbohydrates and lipids on various mechanisms of energy balance and diseases. Adequate measure is necessary to control carbohydrate-lipid interactions as they impact on obesity and diabetes.
Chukwuma Sr C & Tuomilehto J. The “thrifty” hypotheses: clinical and epidemiological significance for non-insulin-dependent diabetes mellitus and cardiovascular disease risk factors. J Cardiovasc Risk., 1998; 5(1): 11-23.
Chukwuma Sr, Chrysanthus. “Probing the dynamics of carbohydrate-lipid interactions." Journal of Advances in Biological and Basic Research 2016; 2 (1): 01-04.
Baynes HW. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J Diabetes Metab., 2015; 6: 541.
Candib LM. Obesity and diabetes in vulnerable populations: reflection and proximal causes. Ann Fam Med, 2007; 5(6): 547-556.
Das UN, Rao AA. Gene expression profile in obesity and type 2 diabetes mellitus. Lipids in Health and Disease, 2007; 6:35.
Kim JB. Dynamic cross talk, between metabolic organs in obesity and metabolic diseases. Exp Mol Med, 2016; 48: e214
Lawrence RD. Interactions of fat and carbohydrate metabolism – Aspects and therapies. Proc R Soc Med, 1941; 35(1): 1-10.
Hardie DG. Organismal carbohydrate and lipid homeostasis. Cold Spring Harbor Perspectives in Biology, 2012; doi: 10.1101/cshperspe.
Musso G, Gambino R, Cassader M. Obesity, diabetes and gut microbiota. The hygiene hypothesis expanded. Diabetes Care, 2010; 33(10): 2277-2284.
Bechmann LP, Hannivoort RA, Gerken G, et al. The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatology, 2012; 56(4): 952-964.
Stunkard AJ, Harris JR, Pedersen NL, McLearn GE. The body mass index of twins who have been reared apart. N Engl J Med, 1990; 332: 1483-1487.
Bouchard C, Tremblay A. Genetic influences on the response of body fat distribution to positive and negative energy balances in human identical twins. Nutr, 1997; 127: 943S-947S.
Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab, 2004; 89: 2583-2589.
Kopelman PG. Obesity as a medical problem. Nature, 2000; 404: 635-643.
Harris MI. Diabetes in America: epidemiology and scope of the problem. Diabetes Care, 1998; 21 Suppl 3: C11-C14.
Singla P, Bardoloi A, Parkash AA. Metabolic effects of obesity: A review. World J Diabetes, 2010; 1(3): 76-88.
Olshansky SJ, Passaro DJ, Hershow et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med, 2005; 352: 1138-1145.
Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diab Metab Res Rev, 1998; 14(4): 263-283.
Dulloo AG, Gubler M, Montani JP, et al. Substrate cycling between de novo lipogenesis, and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity. Proceedings of the Second Fribourg Obesity Research Conference (FORC-2003). Int J Obesity, 2004; 28: S29-S37.
Kelley DE, Mokan M, Simoneau JA, Mandarino LJ. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest, 1993; 92: 91-98.
Frayn KN. The glucose-fatty acid cycle: a physiologic perspective. Biochem Soc Trans, 2003; 31: 1115-1119.
Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA. Effects of fatty acids on glucose production and utilization in man. J Clin Invest, 1983; 72: 1737-1747.
Golay A, Felber JP, Meyer HU et al. Study on lipid metabolism in obesity diabetes. Metabolism, 1984; 33(2): 111-116.
Warth MR, Knopp RH. Metabolism in pregnancy: V. Interactions of Diabetes, Body Weight, Age, and High Carbohydrate Diet. Diabetes, 1977; 26(11): 1056-1062.
Ferreira Z, Ayeleso A, Mukwevh OE. Control of carbohydrate and lipid metabolism by NRF-1 and sirtuins: Implications on type 2 diabetes and obesity. Chem Biol Lett, 2014; 1(2).
Hall RM, Strong AP, Krebs JD. Importance of low carbohydrate diets in diabetes management. Nutr Diet Suppl 2016; 8: 9-19.
Beinstein Dr. Dietary carbohydrate restriction in type 2 diabetes and metabolic syndrome: time for a critical appraisal. Nutrition and Metabolism, 2008 http://www.diabetes.book.com/dietary-carbohydrate-restriction/.
Hung T, Sievenpiper JL, Marchie A, et al. Fat versus carbohydrate in insulin resistance, obesity, diabetes and cardiovascular disease. Curr OpinClin Nutr Metab Care, 2003; 6(2): 165-176.
Steiner SJ, Pfefferkorn MD, Fitzgerald JF & Denne SC. Carbohydrate and lipid metabolism following infliximab therapy in pediatric Chron’s Diease. Pediatric Research, 2008; 64: 673-676.
Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diab Metab Disorders, 2013; 12: 43.
Evans JL, Goldfine, ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev, 2002; 23: 599-622.
Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev, 2009; 2: 270-278.
Bahadoran Z, Golzarand M, Mirmiran P, Saadati N, Azizi F. The association of dietary phytochemical index and cardiometabolic risk factors in adults: Tehran lipid and glucose study. Nutri Metab (Lond), 2012; 9: 70.
Chukwuma Sr C. Is diabetes a model for gene-environment interaction in premature senescence? JABH, 2014; www.iiste.org/Journals/index.php/JBAH/article/view/17380.
Romao I, Roth J. Genetic and environmental interactions in obesity and type 2 diabetes. J Am Dietetic Assoc, 2008; 108(4): S24-S28.
Copyright (c) 2016 Bulletin of Advanced Scientific Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms: a) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. b) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. c) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).